Dicyclomine hydrochloride

Research use only, not for human use.

A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system.

A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms. (In Vivo):Dicyclomine hydrochloride (intraperitoneal injection; 8 mg/kg; daily) exacerbates the cognitive impairments in all the measurements. In addition, the memory impairments are worse in dicyclomine-treated 3xTg-AD mice compared to dicyclomine-treated NonTg mice.Dicyclomine hydrochloride (intraperitoneal injection; 2.0, 4.0, and 8.0 mg/kg; 7 days) produces a highly significant effect on performance in the paired-associates learning (PAL) task in mice.And systemic treatment at lower doses show behavioral impairments in mice in spatial tasks.

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Animal Model:C57Bl/6 mice Dosage:2.0, 4.0, and 8.0 mg/kg Administration:Intraperitoneal injection; daily; 7 days Result:Produced impairments due to actions of the agent outside of the hippocampus.

Dicycloverine

Endocrinology/Hormones

AChR

mAChR

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67-92-5

345.95

C19H36ClNO2

>98% (HPLC)

Soluble in DMSO

Cl.CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1

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(-20℃)

With Ice Pack

≥ 2 years